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Article

Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease.

Human genetics - 1 May 2004

Johansson Annica, Katzov Hagit, Zetterberg Henrik, Feuk Lars, Johansson Boo, Bogdanovic Nenad, Andreasen Niels, Lenhard Boris, Brookes Anthony J, Pedersen Nancy L, Blennow Kaj, Prince Jonathan A

Abstract excerpt

Recent studies have suggested that variants of CYP46A1, encoding cholesterol 24-hydroxylase (CYP46), confer risk for Alzheimer's disease (AD), a prospect substantiated by evidence of genetic association from several quantitative traits related to AD pathology, including cerebrospinal fluid (CSF) levels of the 42 amino-acid cleavage product of beta-amyloid (Abeta42) and the tau protein. In the present study, these...

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Identifiers

PMID: 15034781
DOI: 10.1007/s00439-004-1107-9

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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