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Article

Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism.

Archives of neurology - 1 Jan 2003

Papassotiropoulos Andreas, Streffer Johannes R, Tsolaki Magdalini, Schmid Simon, Thal Dietmar, Nicosia Francesca, Iakovidou Vassiliki, Maddalena Alessia, Lütjohann Dieter, Ghebremedhin Estifanos, Hegi Thomas, Pasch Thomas, Träxler Muriel, Brühl Annette, Benussi Luisa, Binetti Giuliano, Braak Heiko, Nitsch Roger M, Hock Christoph

Abstract excerpt

BACKGROUND: CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby mediates its removal from brain. OBJECTIVE: To study the association of polymorphic sites on CYP46 with Alzheimer disease (AD) traits and with the risk of the developm...

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Identifiers

PMID: 12533085
DOI: 10.1001/archneur.60.1.29

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12533085-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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