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Article

Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer Disease: from risk factors to disease modulators.

Neurobiology of aging - 1 Jul 2004

Borroni Barbara, Archetti Silvana, Agosti Chiara, Akkawi Nabil, Brambilla Cristina, Caimi Luigi, Caltagirone Carlo, Di Luca Monica, Padovani Alessandro

Abstract excerpt

Increasing biological and clinical findings argue for a link between brain cholesterol turnover and Alzheimer Disease (AD), high cerebral levels of the former increasing Abeta load. Cerebral cholesterol elimination involves two mechanisms dependent on Apolipoprotein E (ApoE) and cholesterol 24-hydroxylase (CYP46). The aim of this study was to evaluate an intronic variation in CYP46 (intron 2, T --> C ) along with...

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PMID: 15165699
DOI: 10.1016/j.neurobiolaging.2003.08.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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