Article
Activation of extracellular-regulated kinases by normal and mutant EGF receptors.
Biochimica et biophysica acta - 5 Feb 2001
Lorimer I A, Lavictoire S J
Abstract excerpt
Glioblastoma cells express a mutant EGF receptor (EGFRvIII) that has constitutive tyrosine kinase activity and enhances their tumorigenicity. Here we show that EGFRvIII promotes constitutive phosphorylation of extracellular regulated kinases (ERKs) in glioblastoma cells in the absence of EGF. EGFRvIII also promoted constitutive activation of phosphoinositide 3-kinase in these cells, as assessed by phosphorylation...
Topics
- Dimethyl Sulfoxide
- Enzyme Activation
- Enzyme Inhibitors
- ErbB Receptors
- Mitogen-Activated Protein Kinases
- Mutation
- Phosphoinositide-3 Kinase Inhibitors
- Phosphorylation
- Protein Serine-Threonine Kinases
- Quinazolines
- Tumor Cells, Cultured
- Type C Phospholipases
- Tyrphostins