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Article

Oncogenic activating mutations in the neu/erbB-2 oncogene are involved in the induction of mammary tumors.

Annals of the New York Academy of Sciences - 1 Jan 1999

Chan R, Muller W J, Siegel P M

Abstract excerpt

Amplification and overexpression of erbB-2/neu is an important determinant in the initiation and progression of human breast cancer. Indeed, transgenic mice that over-express the neu proto-oncogene heritably develop mammary adenocarcinomas. Tumorigenesis in these transgenic strains is associated with activation of the intrinsic catalytic activity of Neu. In many of these tumors, activation of Neu occurs as a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10668481
DOI: 10.1111/j.1749-6632.1999.tb08722.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Oncogenic activating mutations in the neu/erbB-2 oncogene are involved in the induction of mammary tumors.PMID 10668481Read ↗

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