Article
Mutations affecting conserved cysteine residues within the extracellular domain of Neu promote receptor dimerization and activation.
Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 1996
Siegel P M, Muller W J
Abstract excerpt
Overexpression of the Neu/ErbB-2 receptor tyrosine kinase has been implicated in the genesis of human breast cancer. Indeed, expression of either activated or wild-type neu in the mammary epithelium of transgenic mice results in the induction of mammary tumors. Previously, we have shown that many...
Topics
- Amino Acid Sequence
- Animals
- Cell Transformation, Neoplastic
- Cells, Cultured
- Conserved Sequence
- Cysteine
- Disulfides
- ErbB Receptors
- Molecular Sequence Data
- Mutation
- Protein Binding
- Protein Conformation
- Rats
- Receptor, ErbB-2
- Sequence Deletion