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Article

Mutations affecting conserved cysteine residues within the extracellular domain of Neu promote receptor dimerization and activation.

Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 1996

Siegel P M, Muller W J

Abstract excerpt

Overexpression of the Neu/ErbB-2 receptor tyrosine kinase has been implicated in the genesis of human breast cancer. Indeed, expression of either activated or wild-type neu in the mammary epithelium of transgenic mice results in the induction of mammary tumors. Previously, we have shown that many of the mammary tumors arising in transgenic mice expressing wild-type neu occur through somatic activating mutations...

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Identifiers

PMID: 8799121
DOI: 10.1073/pnas.93.17.8878
PMCID: PMC38562

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Source receipt: pubmed, retrieved 7 Sept 2026.

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