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Article

Specific inhibition of a pathogenic receptor tyrosine kinase by its transmembrane domain.

Biochimica et biophysica acta - 1 Jan 2011

He Lijuan, Shobnam Nadia, Hristova Kalina

Abstract excerpt

The transmembrane (TM) domains of receptor tyrosine kinases (RTKs) are believed to be important players in RTK signal transduction. However, the degree of specificity and promiscuity of RTK TM domain lateral interactions in mammalian membranes has not been assessed in detail in the literature. A technique to probe the occurrence of interactions between TM domains and their biological significance is to evaluate...

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Identifiers

PMID: 20713021
DOI: 10.1016/j.bbamem.2010.08.007
PMCID: PMC2994959

Genes

FGFR3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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