Biological studies and potential therapeutic applications of monoclonal antibodies and small molecules reactive with the neu/c-erbB-2 protein.

doi:10.1007/BF02789231

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Article

Biological studies and potential therapeutic applications of monoclonal antibodies and small molecules reactive with the neu/c-erbB-2 protein.

Cell biophysics - 1 Jan 1994

Dougall W C, Greene M I

Abstract excerpt

The overexpression of the growth factor receptor p185neu/c-erbB-2 has been observed in a number of human adenocarcinomas and is mechanistically linked to neoplastic growth. Monoclonal antibodies raised against extracellular domains of the p185neu/c-erbB-2 receptor oncoprotein have been utilized t...

Topics

Antibodies, Monoclonal
Down-Regulation
Humans
Neoplasms
Phenotype
Receptor, ErbB-2

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