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Article

Proteasome inhibitor bortezomib promotes a rupture-prone plaque phenotype in ApoE-deficient mice.

Basic research in cardiology - 1 Jan 2010

Van Herck Jozef Leo, De Meyer Guido R Y, Martinet Wim, Bult Hidde, Vrints Christiaan J, Herman Arnold G

Abstract excerpt

The ubiquitin-proteasome system is involved in the development and progression of atherosclerosis. The aim of this study was to investigate whether plaque composition is affected by proteasome function. In vitro, the potent and selective proteasome inhibitor bortezomib induced apoptosis in both cultured smooth muscle cells (SMCs) and activated macrophages. This effect was associated with increased expression of...

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PMID: 19693627
DOI: 10.1007/s00395-009-0054-y

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EBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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