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Article

Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice.

Journal of the American Heart Association - 27 Oct 2017

Vendrov Aleksandr E, Stevenson Mark D, Alahari Samthosh, Pan Hua, Wickline Samuel A, Madamanchi Nageswara R, Runge Marschall S

Abstract excerpt

BACKGROUND: Atherosclerosis progression during aging culminates in the development of vulnerable plaques, which may increase the risk of cardiovascular events. Increased generation and/or decreased scavenging of reactive oxygen species in the vascular wall are major contributors to atherogenesis. We previously showed that superoxide dismutase 2 deficiency increased vascular oxidative stress and reduced aortic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Knockout, ApoE

Share to Mitochondria, Muscle

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Share to Plaque, Atherosclerotic

Share to Rupture, Spontaneous

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Source

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Identifiers

PMID: 29079564
DOI: 10.1161/JAHA.117.006775
PMCID: PMC5721769

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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