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Article

Pioglitazone-Incorporated Nanoparticles Prevent Plaque Destabilization and Rupture by Regulating Monocyte/Macrophage Differentiation in ApoE-/- Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2016

Nakashiro Soichi, Matoba Tetsuya, Umezu Ryuta, Koga Jun-Ichiro, Tokutome Masaki, Katsuki Shunsuke, Nakano Kaku, Sunagawa Kenji, Egashira Kensuke

Abstract excerpt

OBJECTIVE: Inflammatory monocytes/macrophages produce various proteinases, including matrix metalloproteinases, and degradation of the extracellular matrix by these activated proteinases weakens the mechanical strength of atherosclerotic plaques, which results in a rupture of the plaque. Peroxisome proliferator-activated receptor-γ induces a polarity shift of monocytes/macrophages toward less inflammatory...

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PMID: 26821947
DOI: 10.1161/ATVBAHA.115.307057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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