Article
On to the road to degradation: atherosclerosis and the proteasome.
Cardiovascular research - 15 Jan 2010
Herrmann Joerg, Lerman Lilach O, Lerman Amir
Abstract excerpt
Protein metabolism is a central element of every living cell. The ubiquitin-proteasome system (UPS) is an integral part of the protein metabolism machinery mediating post-transcriptional processing and degradation of the majority of intracellular proteins. Over the past few years, remarkable progress has been made in our understanding of the role of the UPS in vascular biology and pathobiology, particularly...
Topics
- Animals
- Atherosclerosis
- Dendritic Cells
- Disease Progression
- Humans
- Nitric Oxide
- Nitric Oxide Synthase Type III
- Oxidative Stress
- Polymorphism, Single Nucleotide
- Proteasome Endopeptidase Complex
- Ubiquitin