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Article

Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/- mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2008

Thorp Edward, Cui Dongying, Schrijvers Dorien M, Kuriakose George, Tabas Ira

Abstract excerpt

OBJECTIVE: Atherosclerotic plaques that are prone to disruption and acute thrombotic vascular events are characterized by large necrotic cores. Necrotic cores result from the combination of macrophage apoptosis and defective phagocytic clearance (efferocytosis) of these apoptotic cells. We previously showed that macrophages with tyrosine kinase-defective Mertk receptor (Mertk(KD)) have a defect in phagocytic...

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Source

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Identifiers

PMID: 18451332
DOI: 10.1161/ATVBAHA.108.167197
PMCID: PMC2575060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/- mice.PMID 18451332Read ↗

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