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Article

Macrophage-specific p53 expression plays a crucial role in atherosclerosis development and plaque remodeling.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2003

Merched Aksam J, Williams Elizabeth, Chan Lawrence

Abstract excerpt

OBJECTIVE: We first showed that absence of p53 accelerates atherosclerosis development in apoE-deficient mice. In this study, we investigated how macrophage-specific loss of p53 function might modulate atherosclerosis development in LDL receptor-deficient mice, a model for familial hypercholesterolemia. METHODS AND RESULTS: We transferred bone marrow cells isolated from p53+/+ and p53-/- mice to lethally...

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Identifiers

PMID: 12842843
DOI: 10.1161/01.ATV.0000084825.88022.53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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