Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death.

doi:10.1161/CIRCULATIONAHA.106.668756

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Article

Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death.

Circulation - 8 May 2007

Oumouna-Benachour Karine, Hans Chetan P, Suzuki Yasuhiro, Naura Amarjit, Datta Rahul, Belmadani Souad, Fallon Kenneth, Woods Cooper, Boulares A Hamid

Abstract excerpt

BACKGROUND: Poly(ADP-ribose) polymerase (PARP) was suggested to play a role in endothelial dysfunction that is associated with a number of cardiovascular diseases. We hypothesized that PARP may play an important role in atherogenesis and that its inhibition may attenuate atherosclerotic plaque development in an experimental model of atherosclerosis. METHODS AND RESULTS: Using a mouse (apolipoprotein E...

Topics

Active Transport, Cell Nucleus
Animals
Aortic Diseases
Apolipoproteins E
Apoptosis
Atherosclerosis
Cells, Cultured
Chemokine CCL2
Cholesterol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Collagen

Crosses, Genetic

Diet, Atherogenic

Drug Evaluation, Preclinical

Foam Cells

Gene Expression Regulation

Genotype

Hydrogen Peroxide

Hypercholesterolemia

Source

Open in PubMed

Identifiers

PMID: 17438151
DOI: 10.1161/CIRCULATIONAHA.106.668756

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