Article
4-phenylbutyrate and valproate treatment attenuates the progression of atherosclerosis and stabilizes existing plaques.
Atherosclerosis - 1 Nov 2017
Huang Aric, Young Tayler L, Dang Vi T, Shi Yuanyuan, McAlpine Cameron S, Werstuck Geoff H
Abstract excerpt
BACKGROUND AND AIMS: Recent evidence suggests that endoplasmic reticulum (ER) stress signaling through glycogen synthase kinase (GSK)-3α/β is involved in the activation of pro-atherosclerotic processes. In this study, we examined the effects of small molecules that interfere with ER stress-GSK3α/β signaling on the progression and regression of atherosclerosis in a mouse model. METHODS: To examine atherosclerotic...
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