Article
Identification of HLA class I-associated amino acid polymorphisms in the HIV-1C proteome.
AIDS research and human retroviruses - 1 Jan 2007
Boutwell Christian L, Essex M
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) evasion of host cytotoxic T lymphocyte (CTL) targeting is linked to the expression of variant amino acid residues, or escape mutations, in positions that alter the normal processing, presentation, or recognition of targeted epitopes. The combined genetic variability of HIV and the class I human leukocyte antigen (HLA) loci makes it difficult to characterize CTL escape...
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