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Article

Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients.

Molecular cancer - 12 Aug 2009

Yamada Hidetaka, Shinmura Kazuya, Goto Masanori, Iwaizumi Moriya, Konno Hiroyuki, Kataoka Hideki, Yamada Masami, Ozawa Takachika, Tsuneyoshi Toshihiro, Tanioka Fumihiko, Sugimura Haruhiko

Abstract excerpt

BACKGROUND: Germline mono-allelic promoter hypermethylation of the MLH1 or MSH2 gene in families with hereditary nonpolyposis colorectal cancer has recently been reported. The purpose of this study was to evaluate if germline promoter hypermethylation of the tumor suppressor gene CDH1 (E-cadherin) might cause predisposition to gastric cancer. METHODS: We prepared two groups of samples, a group of blood samples...

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Source

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Identifiers

PMID: 19671196
DOI: 10.1186/1476-4598-8-63
PMCID: PMC2731731

Genes

CDH1
MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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