Somatic mutations and deletions of the E-cadherin gene predict poor survival of patients with gastric cancer.

doi:10.1200/JCO.2012.44.4612

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Article

Somatic mutations and deletions of the E-cadherin gene predict poor survival of patients with gastric cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Mar 2013

Corso Giovanni, Carvalho Joana, Marrelli Daniele, Vindigni Carla, Carvalho Beatriz, Seruca Raquel, Roviello Franco, Oliveira Carla

Abstract excerpt

PURPOSE: The prognosis of gastric cancer (GC) is poor, and the molecular pathogenesis players are vastly unknown. Surgery remains the primary option in GC treatment. The aim of this study was to investigate the impact of somatic CDH1 alterations in prognosis and survival of patients with GC. PATIENTS AND METHODS: A series of patients with sporadic and familial GC (diffuse and intestinal; n = 246) were analyzed...

Topics

Adult
Aged
Antigens, CD
Cadherins
DNA Methylation
Female
Gene Deletion
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

Kaplan-Meier Estimate

Loss of Heterozygosity

Male

Middle Aged

Mutation

Polymerase Chain Reaction

Prognosis

Source

Open in PubMed

Identifiers

PMID: 23341533
DOI: 10.1200/JCO.2012.44.4612

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23341533-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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