Article
Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer.
The Journal of pathology - 1 Nov 2008
Barber M, Murrell A, Ito Y, Maia A-T, Hyland S, Oliveira C, Save V, Carneiro F, Paterson A L, Grehan N, Dwerryhouse S, Lao-Sirieix P, Caldas C, Fitzgerald R C
Abstract excerpt
Around 25-40% of cases of hereditary diffuse gastric cancer (HDGC) are caused by heterozygous E-cadherin (CDH1) germline mutations. The mechanisms for loss of the second allele still remain unclear. The aims of this study were to elucidate mechanisms for somatic inactivation of the wild-type CDH1...
Topics
- Cadherins
- Carcinoma, Signet Ring Cell
- DNA Methylation
- DNA Mutational Analysis
- Exons
- Gene Expression Regulation, Neoplastic
- Gene Silencing
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Haplotypes
- Humans
- Immunohistochemistry
- Loss of Heterozygosity