Article
Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer.
The Journal of pathology - 1 Nov 2008
Barber M, Murrell A, Ito Y, Maia A-T, Hyland S, Oliveira C, Save V, Carneiro F, Paterson A L, Grehan N, Dwerryhouse S, Lao-Sirieix P, Caldas C, Fitzgerald R C
Abstract excerpt
Around 25-40% of cases of hereditary diffuse gastric cancer (HDGC) are caused by heterozygous E-cadherin (CDH1) germline mutations. The mechanisms for loss of the second allele still remain unclear. The aims of this study were to elucidate mechanisms for somatic inactivation of the wild-type CDH1 allele and to seek evidence for cadherin switching. Archival tumour material was analysed from 16 patients with CDH1...
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