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Article

Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer.

Nature genetics - 1 Sept 2000

Grady W M, Willis J, Guilford P J, Dunbier A K, Toro T T, Lynch H, Wiesner G, Ferguson K, Eng C, Park J G, Kim S J, Markowitz S

Abstract excerpt

Aberrant promoter methylation and the associated loss of gene expression is a common accompaniment of human cancers. Nonetheless, it has been challenging to demonstrate in any given tumour that methylation of a specific gene was causal and not consequent to malignant transformation. In this regard, our attention was drawn to the genesis of gastric cancers in individuals with hereditary diffuse gastric cancer...

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Source

Identifiers

PMID: 10973239
DOI: 10.1038/79120

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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