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Article

The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Dec 2003

Graziano F, Humar B, Guilford P

Abstract excerpt

Loss of function of the E-cadherin gene (CDH1) has been linked with diffuse gastric cancer susceptibility, and germline inactivating mutations in CDH1 characterise the hereditary diffuse gastric cancer (HDGC) syndrome. Hypermethylation in the CDH1 promoter region is a frequent phenomenon in poorly differentiated, diffuse gastric carcinomas and it was identified as the main mechanism for the inactivation of the...

Topics

Cadherins
Cell Transformation, Neoplastic
DNA Methylation
DNA Mutational Analysis
Genetic Markers
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Pedigree
Stomach Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Syndrome

Source

Identifiers

PMID: 14630673
DOI: 10.1093/annonc/mdg486

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-14630673-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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