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Article

MLH1 Promoter Methylation Could Be the Second Hit in Lynch Syndrome Carcinogenesis.

Genes - 9 Nov 2023

Carnevali Ileana Wanda, Cini Giulia, Libera Laura, Sahnane Nora, Facchi Sofia, Viel Alessandra, Sessa Fausto, Tibiletti Maria Grazia

Abstract excerpt

(1) Background: MLH1 hypermethylation is an epigenetic alteration in the tumorigenesis of colorectal cancer (CRC) and endometrial cancer (EC), causing gene silencing, and, as a consequence, microsatellite instability. Commonly, MLH1 hypermethylation is considered a somatic and sporadic event in cancer, and its detection is recognized as a useful tool to distinguish sporadic from inherited conditions (such as,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38003003
DOI: 10.3390/genes14112060
PMCID: PMC10670941

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