Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer.

doi:10.1093/hmg/8.4.607

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Article

Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer.

Human molecular genetics - 1 Apr 1999

Richards F M, McKee S A, Rajpar M H, Cole T R, Evans D G, Jankowski J A, McKeown C, Sanders D S, Maher E R

Abstract excerpt

Inherited mutations in the E-cadherin gene ( CDH1 ) were described recently in three Maori kindreds with familial gastric cancer. Familial gastric cancer is genetically heterogeneous and it is not clear what proportion of gastric cancer susceptibility in non-Maori populations is due to germline CDH1 mutations. Therefore, we screened eight familial gastric cancer kindreds of British and Irish origin for germline...

Topics

Adult
Aged
Base Sequence
Cadherins
Colorectal Neoplasms
DNA Mutational Analysis
DNA, Neoplasm
Exons
Family Health
Female
Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Markers

Genetic Predisposition to Disease

Germ-Line Mutation

Humans

Loss of Heterozygosity

Male

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 10072428
DOI: 10.1093/hmg/8.4.607

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10072428-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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