Article
CDH1 gene mutations do not contribute in hereditary diffuse gastric cancer in Poland.
Familial cancer - 1 Dec 2010
Jakubowska Anna, Lawniczak Małgorzata, Wojnarska Beata, Cybulski Cezary, Huzarski Tomasz, Byrski Tomasz, Tołoczko-Grabarek Aleksandra, Jaworska Katarzyna, Durda Katarzyna, Starzyńska Teresa, Lubiński Jan
Abstract excerpt
Hereditary diffuse gastric cancer (HDGC) is a cancer susceptibility syndrome characterized by a high risk of diffuse stomach cancer and lobular breast cancer. HDGC is caused by germline mutations in the CDH1 gene encoding the E-cadherin which is a member of the transmembrane glycoprotein family r...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antigens, CD
- Cadherins
- DNA Mutational Analysis
- DNA, Neoplasm
- Female
- Genetic Predisposition to Disease
- Genotype
- Germ-Line Mutation
- Humans
- Male