Article
CDH1 gene mutations do not contribute in hereditary diffuse gastric cancer in Poland.
Familial cancer - 1 Dec 2010
Jakubowska Anna, Lawniczak Małgorzata, Wojnarska Beata, Cybulski Cezary, Huzarski Tomasz, Byrski Tomasz, Tołoczko-Grabarek Aleksandra, Jaworska Katarzyna, Durda Katarzyna, Starzyńska Teresa, Lubiński Jan
Abstract excerpt
Hereditary diffuse gastric cancer (HDGC) is a cancer susceptibility syndrome characterized by a high risk of diffuse stomach cancer and lobular breast cancer. HDGC is caused by germline mutations in the CDH1 gene encoding the E-cadherin which is a member of the transmembrane glycoprotein family responsible for calcium-dependent, cell-to-cell adhesion and plays a fundamental role in the maintenance of cell...
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