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Article

MSI phenotype and MMR alterations in familial and sporadic gastric cancer.

International journal of cancer - 1 Apr 2011

Leite Marina, Corso Giovanni, Sousa Sónia, Milanezi Fernanda, Afonso Luís P, Henrique Rui, Soares José Manuel, Castedo Sérgio, Carneiro Fátima, Roviello Franco, Oliveira Carla, Seruca Raquel

Abstract excerpt

Microsatellite instability (MSI) is a major pathway involved in gastric carcinogenesis occurring in 20% of gastric cancer (GC). However, it is not clear whether MSI phenotype preferentially occurs in the sporadic or familial GC, when stringent inclusion criteria are used. The aim of this study was to compare the frequency of MSI and hypermethylation of MLH1 promoter in a large series of familial GC patients...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20533283
DOI: 10.1002/ijc.25495

Genes

MLH1
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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