Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MSI phenotype and MMR alterations in familial and sporadic gastric cancer.

International journal of cancer - 1 Apr 2011

Leite Marina, Corso Giovanni, Sousa Sónia, Milanezi Fernanda, Afonso Luís P, Henrique Rui, Soares José Manuel, Castedo Sérgio, Carneiro Fátima, Roviello Franco, Oliveira Carla, Seruca Raquel

Abstract excerpt

Microsatellite instability (MSI) is a major pathway involved in gastric carcinogenesis occurring in 20% of gastric cancer (GC). However, it is not clear whether MSI phenotype preferentially occurs in the sporadic or familial GC, when stringent inclusion criteria are used. The aim of this study wa...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microsatellite Instability

Share to Microsatellite Repeats

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Share to Nuclear Proteins

Share to Stomach Neoplasms

Source

Identifiers

PMID: 20533283
DOI: 10.1002/ijc.25495

Genes

MLH1
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20533283-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MSI phenotype and MMR alterations in familial and sporadic gastric cancer.PMID 20533283Read ↗

Distinct clinicopathologic and genetic profiles in sporadic gastric cancer with different mutator phenotypes.Semantic proximity Read ↗

Is gastric cancer part of the tumour spectrum of hereditary non-polyposis colorectal cancer? A molecular genetic study.Semantic proximity Read ↗

Somatic mutations in mismatch repair genes in sporadic gastric carcinomas are not a cause but a consequence of the mutator phenotype.Semantic proximity Read ↗

Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high-frequency microsatellite instability.Semantic proximity Read ↗

Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis.Semantic proximity Read ↗

MSI-L gastric carcinomas share the hMLH1 methylation status of MSI-H carcinomas but not their clinicopathological profile.Semantic proximity Read ↗

hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability.Semantic proximity Read ↗

Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers.Semantic proximity Read ↗

Methylation of the hMLH1 promoter but no hMLH1 mutations in sporadic gastric carcinomas with high-level microsatellite instability.Semantic proximity Read ↗

Clinicopathologic Characteristics of Microsatellite Instable Gastric Carcinomas Revisited: Urgent Need for StandardizationSemantic proximity Read ↗

Clinicopathological and molecular alterations in early gastric cancers with the microsatellite instability-high phenotype.Semantic proximity Read ↗

hMLH1 and hMSH2 mutations in families with familial clustering of gastric cancer and hereditary non-polyposis colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.