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Article

Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer.

Gut - 1 Mar 2001

Wheeler J M, Kim H C, Efstathiou J A, Ilyas M, Mortensen N J, Bodmer W F

Abstract excerpt

BACKGROUND: Ulcerative colitis associated colorectal cancer (UCACRC) has several distinctive clinicopathological and genetic features which differ from sporadic colorectal cancer (SCRC). Hypermethylation of the E-cadherin gene (CDH1) has not been described previously in colorectal cancer. AIMS: A panel of SCRC and UCACRC were investigated for mutations in CDH1, and for hypermethylation of the promoter region of...

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Share to Cadherins
Share to Colitis, Ulcerative
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Gene Expression

Share to Polymorphism, Single-Stranded Conformational

Share to Promoter Regions, Genetic

Share to Statistics, Nonparametric

Source

Open in PubMed Open full text

Identifiers

PMID: 11171827
DOI: 10.1136/gut.48.3.367
PMCID: PMC1760130

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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