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Article

Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population.

Respiratory research - 11 Aug 2009

Siedlinski Mateusz, Postma Dirkje S, Boer Jolanda M A, van der Steege Gerrit, Schouten Jan P, Smit Henriette A, Boezen H Marike

Abstract excerpt

BACKGROUND: The metabolism of xenobiotics plays an essential role in smoking related lung function loss and development of Chronic Obstructive Pulmonary Disease. Nuclear Factor Erythroid 2-Like 2 (NFE2L2 or NRF2) and its cytosolic repressor Kelch-like ECH-associated protein-1 (KEAP1) regulate transcription of enzymes involved in cellular detoxification processes and Nfe2l2-deficient mice develop tobacco-induced...

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Source

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Identifiers

PMID: 19671143
DOI: 10.1186/1465-9921-10-73
PMCID: PMC2738671

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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