Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease.

Physiological genomics - 1 Aug 2012

Sandford Andrew J, Malhotra Deepti, Boezen H Marike, Siedlinski Mateusz, Postma Dirkje S, Wong Vivien, Akhabir Loubna, He Jian-Qing, Connett John E, Anthonisen Nicholas R, Paré Peter D, Biswal Shyam

Abstract excerpt

An oxidant-antioxidant imbalance in the lung contributes to the development of chronic obstructive pulmonary disease (COPD) that is caused by a complex interaction of genetic and environmental risk factors. Nuclear erythroid 2-related factor 2 (NFE2L2 or NRF2) is a critical molecule in the lung's defense mechanism against oxidants. We investigated whether polymorphisms in the NFE2L2 pathway affected the rate of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to Demography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

Share to NF-E2-Related Factor 2

Share to Pulmonary Disease, Chronic Obstructive

Share to Respiratory Function Tests

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 22693272
DOI: 10.1152/physiolgenomics.00027.2012
PMCID: PMC3774584

Genes

FOSL1
KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease.PMID 22693272Read ↗

Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population.Semantic proximity Read ↗

NFE2L2 polymorphisms, mortality, and metabolism in the general population.Semantic proximity Read ↗

An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1: a longitudinal retrospective cohort study.Semantic proximity Read ↗

NFE2L2 gene variants and susceptibility to childhood-onset asthma.Semantic proximity Read ↗

Oxidative Stress and Antioxidants in the Pathogenesis of Pulmonary Fibrosis: A Potential Role for Nrf2Semantic proximity Read ↗

Genome-wide association study of lung function decline using elastic-net regression: a prospective analysis in Korean cohort.Semantic proximity Read ↗

Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD.Semantic proximity Read ↗

Genome-Wide Association Analysis of Rapid Decline in Lung Function: Analysis From the Korean Genome and Epidemiology Study.Semantic proximity Read ↗

Genome-wide association study of lung function decline in adults with and without asthma.Semantic proximity Read ↗

Variants of asthma and chronic obstructive pulmonary disease genes and lung function decline in aging.Semantic proximity Read ↗

Associations of the NRF2/KEAP1 pathway and antioxidant defense gene polymorphisms with chronic obstructive pulmonary diseaseSemantic proximity Read ↗

Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.