Article
Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels.
Molecular and cellular biology - 1 Jun 2013
Suzuki Takafumi, Shibata Tatsuhiro, Takaya Kai, Shiraishi Kouya, Kohno Takashi, Kunitoh Hideo, Tsuta Koji, Furuta Koh, Goto Koichi, Hosoda Fumie, Sakamoto Hiromi, Motohashi Hozumi, Yamamoto Masayuki
Abstract excerpt
Transcription factor Nrf2 (NF-E2-related factor 2) is essential for oxidative and electrophilic stress responses. While it has been well characterized that Nrf2 activity is tightly regulated at the protein level through proteasomal degradation via Keap1 (Kelch-like ECH-associated protein 1)-mediated ubiquitination, not much attention has been paid to the supply side of Nrf2, especially regulation of Nrf2 gene...
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