Article
Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophrenia.
Archives of general psychiatry - 1 Nov 2009
Prata Diana P, Mechelli Andrea, Picchioni Marco M, Fu Cynthia H Y, Toulopoulou Timothea, Bramon Elvira, Walshe Muriel, Murray Robin M, Collier David A, McGuire Philip
Abstract excerpt
CONTEXT: The dopamine transporter plays a key role in the regulation of central dopaminergic transmission, which modulates cognitive processing. Disrupted dopamine function and impaired executive processing are robust features of schizophrenia. OBJECTIVE: To examine the effect of a polymorphism in the dopamine transporter gene (the variable number of tandem repeats in the 3' untranslated region) on brain function...
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