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Article

Epistatic interaction of BDNF and COMT on the frontostriatal system.

Neuroscience - 9 Jul 2015

Wang C, Liu B, Long H, Fan L, Li J, Zhang X, Qiu C, Yu C, Jiang T

Abstract excerpt

The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Beh...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25896799
DOI: 10.1016/j.neuroscience.2015.04.014

Genes

COMT
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25896799-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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