Article
Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells.
Oncogene - 8 Mar 2001
Imamura O, Fujita K, Shimamoto A, Tanabe H, Takeda S, Furuichi Y, Matsumoto T
Abstract excerpt
Bloom syndrome (BS) is a recessive human genetic disorder characterized by short stature, immunodeficiency and an elevated risk of malignancy. The gene mutated in BS, BLM, encodes a RecQ-type DNA helicase. BS cells have mutator phenotypes such as hyper-recombination, chromosome instability and an increased frequency of sister chromatid exchange (SCE). To define the primary role of BLM, we generated BLM(-/-)...
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