Article

Functions of the Bloom Syndrome Helicase N-terminal Intrinsically Disordered Region

2024-04-15

Abstract excerpt

Bloom Syndrome helicase (Blm) is a RecQ family helicase involved in DNA repair, cell-cycle progression, and development. Pathogenic variants in human BLM cause the autosomal recessive disorder Bloom Syndrome, characterized by predisposition to numerous types of cancer. Prior studies of Drosophila Blm mutants lacking helicase activity or protein have shown sensitivity to DNA damaging agents, defects in repairing...

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Literature Corpus work: b1a9c77b-8de5-5499-b76a-ab4f44cedeca
DOI: 10.1101/2024.04.12.589165

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