Article
Intrachromosomal recombination between highly diverged DNA sequences is enabled in human cells deficient in Bloom helicase.
DNA repair - 1 May 2016
Wang Yibin, Li Shen, Smith Krissy, Waldman Barbara Criscuolo, Waldman Alan S
Abstract excerpt
Mutation of Bloom helicase (BLM) causes Bloom syndrome (BS), a rare human genetic disorder associated with genome instability, elevation of sister chromatid exchanges, and predisposition to cancer. Deficiency in BLM homologs in Drosophila and yeast brings about significantly increased rates of recombination between imperfectly matched sequences ("homeologous recombination," or HeR). To assess whether BLM...
Topics
- Base Sequence
- Bloom Syndrome
- Cell Line
- Chromosomes, Human
- DNA Breaks, Double-Stranded
- DNA Repair
- Homologous Recombination
- Humans
- Mutation
- RecQ Helicases