Origins of mtDNA mutations in ageing.

doi:10.1042/EBC20160090

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Article

Origins of mtDNA mutations in ageing.

Essays in biochemistry - 15 Jul 2017

Szczepanowska Karolina, Trifunovic Aleksandra

Abstract excerpt

MtDNA mutations are one of the hallmarks of ageing and age-related diseases. It is well established that somatic point mutations accumulate in mtDNA of multiple organs and tissues with increasing age and heteroplasmy is universal in mammals. However, the origin of these mutations remains controversial. The long-lasting hypothesis stating that mtDNA mutations emanate from oxidative damage via a self-perpetuating...

Topics

Aging
Animals
DNA, Mitochondrial
Humans
Mutation
Oxidative Stress
Reactive Oxygen Species

Source

Open in PubMed

Identifiers

PMID: 28698307
DOI: 10.1042/EBC20160090

Genes

POLG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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