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Article

HLA-DQB10602 determines disease susceptibility in a new "humanized" multiple sclerosis model in HLA-DR15 (DRB11501;DQB1*0602) transgenic mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2009

Kaushansky Nathali, Altmann Daniel M, Ascough Stephanie, David Chella S, Lassmann Hans, Ben-Nun Avraham

Abstract excerpt

The susceptibility to multiple sclerosis (MS), a chronic neurological autoimmune disease that primarily targets CNS myelin, has long been associated with HLA class-II genes. Although several other HLA and non-HLA disease predisposing alleles have been identified, alleles of the HLA-DR15 haplotype (DRB1*1501, DRB5*0101, and DQB1*0602) remain the strongest susceptibility factor. Many studies have suggested that the...

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Identifiers

PMID: 19648275
DOI: 10.4049/jimmunol.0900784

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MOBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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