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Article

DQB10602 rather than DRB11501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP)

8 Feb 2012

Abstract excerpt

BACKGROUND: Multiple sclerosis (MS) is associated with pathogenic autoimmunity primarily focused on major CNS-myelin target antigens including myelin basic protein (MBP), proteolipidprotein (PLP), myelin oligodendrocyte protein (MOG). MS is a complex trait whereby the HLA genes, particularly class-II genes of HLA-DR15 haplotype, dominate the genetic contribution to disease-risk. Due to strong linkage...

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PMID: 22316121
DOI: 10.1186/1742-2094-9-29

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