HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis.

doi:10.1016/j.cell.2020.09.054

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Article

HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis.

Cell - 25 Nov 2020

Wang Jian, Jelcic Ivan, Mühlenbruch Lena, Haunerdinger Veronika, Toussaint Nora C, Zhao Yingdong, Cruciani Carolina, Faigle Wolfgang, Naghavian Reza, Foege Magdalena, Binder Thomas M C, Eiermann Thomas, Opitz Lennart, Fuentes-Font Laura, Reynolds Richard, Kwok William W, Nguyen Julie T, Lee Jar-How, Lutterotti Andreas, Münz Christian, Rammensee Hans-Georg, Hauri-Hohl Mathias, Sospedra Mireia, Stevanovic Stefan, Martin Roland

Abstract excerpt

The HLA-DR15 haplotype is the strongest genetic risk factor for multiple sclerosis (MS), but our understanding of how it contributes to MS is limited. Because autoreactive CD4+ T cells and B cells as antigen-presenting cells are involved in MS pathogenesis, we characterized the immunopeptidomes of the two HLA-DR15 allomorphs DR2a and DR2b of human primary B cells and monocytes, thymus, and MS brain tissue....

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Identifiers

PMID: 33091337
DOI: 10.1016/j.cell.2020.09.054
PMCID: PMC7707104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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