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Article

HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2009

Zota Victor, Nemirovsky Anna, Baron Rona, Fisher Yair, Selkoe Dennis J, Altmann Daniel M, Weiner Howard L, Monsonego Alon

Abstract excerpt

Active amyloid beta-peptide (Abeta) immunization of patients with Alzheimer's disease (AD) caused meningoencephalitis in approximately 6% of immunized patients in a clinical trial. In addition, long-term studies of AD patients show varying degrees of Abeta Ab responses, which correlate with the extent of Abeta clearance from the brain. In this study, we examined the contribution of various HLA-DR alleles to these...

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Source

Identifiers

PMID: 19675171
DOI: 10.4049/jimmunol.0900620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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