Article
T cell response to myelin basic protein in the context of the multiple sclerosis-associated HLA-DR15 haplotype: peptide binding, immunodominance and effector functions of T cells.
Journal of neuroimmunology - 1 Aug 1997
Vergelli M, Kalbus M, Rojo S C, Hemmer B, Kalbacher H, Tranquill L, Beck H, McFarland H F, De Mars R, Long E O, Martin R
Abstract excerpt
In this study, we evaluated the role of the two functional HLA-DR heterodimers, DR2a (DR alpha paired with the beta chain encoded by DRB5*0101) and DR2b (DR alpha paired with the beta chain encoded by DRB1*1501), that are coexpressed in the multiple sclerosis (MS)-associated haplotype HLA-DR15 Dw...
Topics
- Alleles
- Amino Acid Sequence
- Cathepsin D
- Cell Line
- Clone Cells
- Cytotoxicity, Immunologic
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- HLA-DR2 Antigen
- Haplotypes
- Humans
- Hydrolysis
- Immunodominant Epitopes
- Molecular Sequence Data