Article
T cell response to myelin basic protein in the context of the multiple sclerosis-associated HLA-DR15 haplotype: peptide binding, immunodominance and effector functions of T cells.
Journal of neuroimmunology - 1 Aug 1997
Vergelli M, Kalbus M, Rojo S C, Hemmer B, Kalbacher H, Tranquill L, Beck H, McFarland H F, De Mars R, Long E O, Martin R
Abstract excerpt
In this study, we evaluated the role of the two functional HLA-DR heterodimers, DR2a (DR alpha paired with the beta chain encoded by DRB5*0101) and DR2b (DR alpha paired with the beta chain encoded by DRB1*1501), that are coexpressed in the multiple sclerosis (MS)-associated haplotype HLA-DR15 Dw2, in presenting myelin basic protein (MBP) peptides to MBP-specific T cell lines (TCL). Our results show that both...
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