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Article

Myelin basic protein-specific TCR/HLA-DRB501:01 transgenic mice support the etiologic role of DRB501:01 in multiple sclerosis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2012

Quandt Jacqueline A, Huh Jaebong, Baig Mirza, Yao Karen, Ito Naoko, Bryant Mark, Kawamura Kazuyuki, Pinilla Clemencia, McFarland Henry F, Martin Roland, Ito Kouichi

Abstract excerpt

Genetic susceptibility to multiple sclerosis (MS) has been linked to the HLA-DR15 haplotype consisting of DRB1*15:01(DR2b) and DRB5*01:01(DR2a) alleles. Given almost complete linkage disequilibrium of the two alleles, recent studies suggested differential roles in susceptibility (DR2b) or protection from MS (DR2a). Our objective was to assess the potential contribution of DR2a to disease etiology in MS using a...

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Identifiers

PMID: 22888134
DOI: 10.4049/jimmunol.1103087
PMCID: PMC3436970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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