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Article

Attenuated immune control of Epstein-Barr virus in humanized mice is associated with the multiple sclerosis risk factor HLA-DR15.

European journal of immunology - 1 Jan 2021

Zdimerova Hana, Murer Anita, Engelmann Christine, Raykova Ana, Deng Yun, Gujer Cornelia, Rühl Julia, McHugh Donal, Caduff Nicole, Naghavian Reza, Pezzino Gaetana, Capaul Riccarda, Zbinden Andrea, Ferlazzo Guido, Lünemann Jan D, Martin Roland, Chatterjee Bithi, Münz Christian

Abstract excerpt

Immune responses to Epstein-Barr virus (EBV) infection synergize with the main genetic risk factor HLA-DRB1*15:01 (HLA-DR15) to increase the likelihood to develop the autoimmune disease multiple sclerosis (MS) at least sevenfold. In order to gain insights into this synergy, we investigated HLA-DR15 positive human immune compartments after reconstitution in immune-compromised mice (humanized mice) with and without...

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PMID: 32949466
DOI: 10.1002/eji.202048655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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