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Article

Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 29 Jul 2009

Tavoulari Sotiria, Forrest Lucy R, Rudnick Gary

Abstract excerpt

Serotonin transporter (SERT) is the main target for widely used antidepressant agents. Several of these drugs, including imipramine, citalopram, sertraline, and fluoxetine (Prozac), bound more avidly to SERT in the presence of Cl(-). In contrast, Cl(-) did not enhance cocaine or paroxetine bindin...

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Source

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Identifiers

PMID: 19641126
DOI: 10.1523/JNEUROSCI.0440-09.2009
PMCID: PMC3012355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19641126-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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