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Article

Helix XI contributes to the entrance of the serotonin transporter permeation pathway.

Protein science : a publication of the Protein Society - 1 Oct 2008

Torres-Altoro Melissa I, White Kellie J, Rodríguez Gustavo J, Nichols David E, Barker Eric L

Abstract excerpt

The sodium-dependent transporters for dopamine, norepinephrine, and serotonin that regulate neurotransmission, also translocate the neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)). Previous studies implicated residues in transmembrane helix (TMH) XI of DAT as important sites for MPP(+) transport. We examined the importance of TMH XI residues F551 and F556 for MPP(+) translocation by human SERT. Mutations at hSERT...

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Identifiers

PMID: 18628241
DOI: 10.1110/ps.036749.108
PMCID: PMC2548363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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