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Article

Identification of a chloride ion binding site in Na+/Cl -dependent transporters.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jul 2007

Forrest Lucy R, Tavoulari Sotiria, Zhang Yuan-Wei, Rudnick Gary, Honig Barry

Abstract excerpt

The recent determination of the crystal structure of the leucine transporter from Aquifex aeolicus (aaLeuT) has provided significant insights into the function of neurotransmitter:sodium symporters. Transport by aaLeuT is Cl(-) independent, whereas many neurotransmitter:sodium symporters from higher organisms depend on Cl(-) ions. However, the only Cl(-) ion identified in the aaLeuT structure interacts with...

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Identifiers

PMID: 17652169
DOI: 10.1073/pnas.0705600104
PMCID: PMC1937540

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