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Article

Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling.

Neuron - 30 Jul 2009

Verstreken Patrik, Ohyama Tomoko, Haueter Claire, Habets Ron L P, Lin Yong Q, Swan Laura E, Ly Cindy V, Venken Koen J T, De Camilli Pietro, Bellen Hugo J

Abstract excerpt

Synaptic vesicle endocytosis is critical for maintaining synaptic communication during intense stimulation. Here we describe Tweek, a conserved protein that is required for synaptic vesicle recycling. tweek mutants show reduced FM1-43 uptake, cannot maintain release during intense stimulation, and harbor larger than normal synaptic vesicles, implicating it in vesicle recycling at the synapse. Interestingly, the...

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Identifiers

PMID: 19640479
DOI: 10.1016/j.neuron.2009.06.017
PMCID: PMC2759194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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