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Article

Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction.

PloS one - 1 Jan 2016

Sclip Alessandra, Bacaj Taulant, Giam Louise R, Südhof Thomas C

Abstract excerpt

Extended synaptotagmins (ESyts) are endoplasmic reticulum (ER) proteins composed of an N-terminal transmembrane region, a central SMP-domain, and five (ESyt1) or three C-terminal cytoplasmic C2-domains (ESyt2 and ESyt3). ESyts bind phospholipids in a Ca2+-dependent manner via their C2-domains, are localized to ER-plasma membrane contact sites, and may catalyze lipid exchange between the plasma membrane and the ER...

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Identifiers

PMID: 27348751
DOI: 10.1371/journal.pone.0158295
PMCID: PMC4922586

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