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Article

Discrete residues in the c(2)b domain of synaptotagmin I independently specify endocytic rate and synaptic vesicle size.

Neuron - 6 Apr 2006

Poskanzer Kira E, Fetter Richard D, Davis Graeme W

Abstract excerpt

It has been demonstrated that synapses lacking functional synaptotagmin I (Syt I) have a decreased rate of synaptic vesicle endocytosis. Beyond this, the function of Syt I during endocytosis remains undefined. Here, we demonstrate that a decreased rate of endocytosis in syt(null) mutants correlates with a stimulus-dependent perturbation of membrane internalization, assayed ultrastructurally. We then separate the...

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Identifiers

PMID: 16600855
DOI: 10.1016/j.neuron.2006.02.021

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