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Article

A Ca2+ channel differentially regulates Clathrin-mediated and activity-dependent bulk endocytosis.

PLoS biology - 1 Apr 2017

Yao Chi-Kuang, Liu Yu-Tzu, Lee I-Chi, Wang You-Tung, Wu Ping-Yen

Abstract excerpt

Clathrin-mediated endocytosis (CME) and activity-dependent bulk endocytosis (ADBE) are two predominant forms of synaptic vesicle (SV) endocytosis, elicited by moderate and strong stimuli, respectively. They are tightly coupled with exocytosis for sustained neurotransmission. However, the underlying mechanisms are ill defined. We previously reported that the Flower (Fwe) Ca2+ channel present in SVs is incorporated...

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Identifiers

PMID: 28414717
DOI: 10.1371/journal.pbio.2000931
PMCID: PMC5393565

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